NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

Figure 1

The NALP3 inflammasome is activated in the glomeruli of DN mice. (a) Western blotting gel document showing the expression of NALP3, ASC, active caspase-1, and active IL-1β in the glomerular lysate of DN mice. (b) Summarized data presenting the protein expression of NALP3, ASC, active caspase-1, and active IL-1β in the glomeruli of DN mice (). Ctrl mice: control mice; DN mice: diabetic nephropathy mice. compared with Ctrl mice. (c) Dual immunofluorescence staining of IL-1β and synaptopodin in healthy control and DN patients. Original magnification: 400.

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