Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight

Figure 4

Hepatic glycogen stores declined following carrageenan. (a) Hepatic glycogen was higher in control and HFD groups in blood samples obtained at 50 weeks (; ). (b)–(e) Representative sections of mouse liver stained for glycogen by periodic acid Schiff (PAS) in control (b), carrageenan-exposed (c), HFD alone (d), and HFD + carrageenan-exposed (e) mice after 52 weeks showed more intense staining in control and HFD tissues. Marker = 10 μm; original magnification 100x; CGN = carrageenan; HFD = high fat diet.

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