Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease

Figure 4

Effects of DC on the expression of ICAM-1, TNF, IL-6, IL-1, and the activation of NF-B signaling pathway. (a) Retinal mRNA expression of ICAM-1 (ICAM1), TNF (Tnf), IL-6 (Il6), IL-1 (Il1b). Data are expressed as means ± SD ( for control, for DM, for DM+DC 30 mg/kg, and for DM+DC 300 mg/kg). , compared to control; ^#, ^## compared to DM without DC. (b) Retinal expression of ICAM-1 and phosphorylated p65, IB, and IKK. ICAM-1 and phosphorylated p65, IB, and IKK are detected by immunoblotting using specific antibody. Results represent at least three repeated experiments. (c) Quantitative densitometric analysis of ICAM-1 and phosphorylated p65, IB, and IKK. Data are expressed as means ± SD ( for control, for DM, for DM+DC 30 mg/kg, and for DM+DC 300 mg/kg). , compared to control; ^#, ^##, and ^### compared to DM without DC.

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