Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions

Figure 2

Immunohistochemistry ((a)–(h)) for the androgen receptor and quantification of AR-positive cells (i) in the acinar epithelium of rat ventral prostate (brown nuclei). (a) Short-term control (C1); (b) short-term control treated with MLT (M1); (c) short-term untreated diabetic (D1); (d) short-term diabetic treated with MLT (MD1); (e) long-term control (C2); (f) long-term control treated with MLT (M2); (g) long-term untreated diabetic (D2); (h) long-term diabetic treated with MLT (MD2). e: epithelium; l: lumen; s: stroma; arrow: AR-positive cells. Magnification: 400x, bar = 25 μm. (i) AR-positive epithelial cells frequency (%); light bars: short-term experiment and dark bars: long-term experiment ( animals/group). Different lowercase letters indicate significant differences between experimental groups C1, M1, D1, and MD1 (parametric data), and different capital letters indicate significant differences between groups C2, M2, D2, and MD2 (nonparametric data).

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