Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction

Figure 2

In diabetic mice, plasma-derived endogenous CTGF (eCTGF) accounts for 37% of urinary eCTGF (ueCTGF), while intrarenally derived CTGF accounts for 63% of ueCTGF (median with interquartile range).