Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction

Figure 3

In diabetic kidneys, CTGF mRNA expression is increased in glomeruli and medullary tubules. (a) In situ hybridization of CTGF in control and diabetic mice, with little staining in control mice, and clear staining mainly in glomeruli and medullary tubules. (b) Quantitative RT-PCR of CTGF, showing increased levels in diabetic mice versus control mice, both (Mann-Whitney test).

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