Research Article
Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction
Table 1
Characteristics of control mice and diabetic mice (parameters at termination of the study).
| | Control | Diabetes |
| | 8 | 19 | Plasma glucose (mmol/L) | 11.6 (9.8–13.1) | 21.5 (18.1–27.8)a | Body weight at start (g) | 25.5 (24.7–26.9) | 26.0 (24.9–27.0) | Body weight at termination (g) | 25.6 (24.7–27.9) | 22.1 (21.1–23.2)a | Kidney weight (mg) | 150 (141–160) | 139 (128–148)a | Kidney weight/body weight (mg/g) | 5.7 (5.4–5.9) | 6.3 (5.9–6.7)a | GFR (mL kg−1 min−1; inulin) | 10.5 (8.4–12.4) | 7.7 (6.3–9.4)a | AER (μg/24 h) | 135 (77–158) | 400 (242–544)a | Plasma CTGF (pmol/l) | 230 (185–295) | 340 (290–370)a | Urinary CTGF (fmol/24 h) | ≤57 | 999 (190–2946)a |
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Data are median (interquartile range); a versus control mice in Mann-Whitney test.
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