Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction

Table 1

Characteristics of control mice and diabetic mice (parameters at termination of the study).

	Control	Diabetes
	8	19
Plasma glucose (mmol/L)	11.6 (9.8–13.1)	21.5 (18.1–27.8)^a
Body weight at start (g)	25.5 (24.7–26.9)	26.0 (24.9–27.0)
Body weight at termination (g)	25.6 (24.7–27.9)	22.1 (21.1–23.2)^a
Kidney weight (mg)	150 (141–160)	139 (128–148)^a
Kidney weight/body weight (mg/g)	5.7 (5.4–5.9)	6.3 (5.9–6.7)^a
GFR (mL kg^−1 min^−1; inulin)	10.5 (8.4–12.4)	7.7 (6.3–9.4)^a
AER (μg/24 h)	135 (77–158)	400 (242–544)^a
Plasma CTGF (pmol/l)	230 (185–295)	340 (290–370)^a
Urinary CTGF (fmol/24 h)	≤57	999 (190–2946)^a

Data are median (interquartile range); ^a versus control mice in Mann-Whitney test.