Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction

Table 3

Association of urinary CTGF with various damage markers in diabetic patients.

Damage marker	Model I		Model II		Model III		Model IV
		P	Standard	P	Standard	P	Standard	P
IgG4	0.155	0.009	0.106	0.063	−0.064	0.264	−0.058	0.302
1M	0.378	<0.001	0.293	<0.001
2M	0.335	<0.001	0.226	<0.001
KIM-1	0.226	<0.001	0.176	0.002
NAG	0.166	0.005	0.145	0.012
NGAL	0.235	<0.001	0.187	0.001
H-FABP	0.371	<0.001	0.387	<0.001	0.258	<0.001	0.251	0.001
Proximal tubular reabsorption (PTR) -score					0.159	0.014
Proximal tubular injury (PTI) -score					0.165	0.004
Combined proximal tubule (PT) -score							0.266	<0.001
Plasma CTGF	0.330	<0.001	Variable	Variable	0.177	0.007	0.180	0.006

Model I: univariate (Spearman’s ρ); model II includes age, sex, eGFR, duration of diabetes, BMI, HbA1c, plasma CTGF, and individual urinary marker; model III includes age, sex, eGFR, duration of diabetes, BMI, HbA1c, plasma CTGF, IgG4, PTR -score, PTI -score, and H-FABP; model IV includes age, sex, eGFR, duration of diabetes, BMI, HbA1c, plasma CTGF, IgG4, PT -score, and H-FABP. Standard varies from 0.175 to 0.256 and P value from <0.001 to 0.009, depending on the urinary marker included in the model.