A New Approach to Define and Diagnose Cardiometabolic Disorder in Children
Table 4
Sensitivity analyses of changing one parameter in the MetS outcome with another covering the same trait. At the bottom CRF and waist circumference are compared against the same MetS outcome. For each comparison a cutoff point in -score was chosen, which selected the same proportion of cases.
Odds ratios (95% CI) for quartiles of fitness
1st quartile
2nd quartile
3rd quartile
4th quartile
MetS without fatness (TG + HOMA + BP − HDL)
5.2 (3.8–7.2)
2.0 (1.4–2.9)
1.8 (1.2–2.6)
1 (ref.)
MetS with waist
19.5 (10.8–35.1)
3.7 (2.0–7.1)
2.7 (1.4–5.3)
1 (ref.)
MetS with sum4skin
30.0 (15.3–58.6)
5.0 (2.4–10.3)
3.2 (1.5–6.8)
1 (ref.)
MetS with BMI
21.8 (12.2–39.3)
4.8 (2.5–9.0)
2.7 (1.4–5.2)
1 (ref.)
MetS with bioimpedance (%fat)
11.7 (5.2–26.6)
2.2 (0.8–5.6)
1.0 (0.3–3.0)
1 (ref.)
MetS with waist circumference
10.9 (4.2–28.4)
2.3 (0.8–6.9)
1.6 (0.5–5.2)
1 (ref.)
MetS with HOMA
19.5 (10.8–35.1)
3.7 (2.0–7.1)
2.7 (1.4–5.3)
1 (ref.)
MetS with glucose
13.0 (7.7–21.8)
2.3 (1.3–4.3)
1.2 (0.6–2.4)
1 (ref.)
MetS (TG + HOMA + sysBP + waist − HDL)
18.3 (7.8–43.3)
3.2 (1.2–8.6)
2.6 (1.0–7.1)
1 (ref.)
Adding leptin
75.2 (18.2–309.8)
7.6 (1.6–35.4)
5.2 (1.1–25.0)
1 (ref.)
MetS (TG + HOMA + sysBP + waist − HDL)
22.7 (10.8–47.7)
3.1 (1.3–7.5)
2.3 (0.9–5.6)
1 (ref.)
Adding APOA1
19.8 (9.8–40.1)
2.8 (1.2–6.4)
2.0 (0.8–4.8)
1 (ref.)
Adding APOB
24.3 (10.4–56.7)
4.5 (1.7–11.6)
2.5 (0.9–7.0)
1 (ref.)
Adding adiponectin
13.5 (6.5–27.9)
1.9 (0.8–4.9)
2.0 (0.8–4.7)
1 (ref.)
Adding CRP
12.7 (7.4–21.7)
2.8 (1.5–5.3)
1.8 (1.0–3.5)
1 (ref.)
MetS (TG + HOMA + BP − HDL) against CRF quartiles#
5.2 (3.8–7.2)
2.0 (1.4–2.9)
1.8 (1.2–2.6)
1 (ref.)
MetS (TG + HOMA + BP − HDL) against waist quartiles#
1 (ref.)
1.1 (0.8–1.6)
1.2 (0.9–1.7)
4.1 (3.1–5.4)
Adding CRF against waist quartiles
1 (ref.)
1.8 (1.1–3.0)
2.5 (1.5–4.1)
14.8 (9.6–22.9)
These two analyses compare the strength between quartiles of fitness and quartiles of waist circumference against the same MetS outcome. Data only available in CoSCIS, which is why estimates of quartiles of fitness in relation to MetS including waist circumference differ from analysis above.
