Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients

Figure 4

Decreased NO bioavailability is associated with e-PASP, DM, and the Hp 2-2 phenotype. (a) Association of low plasma nitrite and e-PASP. 67% of study participants with nitrite levels below 0.2 μM had high e-PASP levels while only 36% of individuals with normal nitrite levels had high e-PASP (). (b) Association of the Hp phenotype and low plasma nitrite and high e-PASP. 71% of individuals with low nitrite levels and high e-PASP had the Hp 2-2 phenotype ( compared to Hp 2-1 phenotype). (c) Association of DM and the Hp 2-2 genotype with low plasma nitrite and high e-PASP. 90% of all Hp 2-2 individuals who had low nitrite and high e-PASP had DM ( comparing prevalence of DM versus non-DM in this Hp 2-2 cohort with low nitrite and high e-PASP).

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