Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin

Figure 5

Quantification of (a) Ang I, (b) Ang II, and (c) Ang-(1–7) levels in kidney tissue of CT (white column) and D (black column) mice having 1 or 3 copies of the Ace gene at twelve weeks of experimental period assessed by HPLC. Values represent mean ± S.E.M, . Two-way ANOVA showed : diabetic versus control. : 3 copies control group versus 1 copy control group. : 3 copies diabetic group versus 1 copy diabetic group.

(a)

(b)

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