Research Article
Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA
Table 3
LOD score summary table.
| | LOD (HLOD) scores | | Phenotype | 42 cM peak | 52 cM peak | 64 cM peak |
| | Any complication | 2.6 (4.4) | 4.0 (5.3) | −1 (2.6) | | Retinopathy | 3.6 (5.0) | 3.6 (5.0) | −1.5 (2.2) | | Nephropathy | −2.0 (0.0) | 1.3 (1.4) | 2.0 (2.2) | | Retinopathy + nephropathy analyzed together | 3.2 (4.8) | 4.0 (5.2) | −1.1 (2.3) |
| | Stratification (retinopathy only) | | DRB1*03:01 | 3.0 (3.9) | 5.1 (5.3) | 3.1 (3.4) | | DRB1*04:01 | 4.1 (4.1) | 4.2 (4.2) | −0.5 (0.9) | | DRB1*03:01/X | 0.9 (1.6) | 2.0 (2.2) | 2.0 (2.2) | | (X≠DRB1*04:01) | | DRB1*04:01/X | 2.5 (2.5) | 1.4 (1.4) | −1.0 (0.0) | | (X≠DRB1*03:01) |
|
|
Numbers in parentheses are HLODs.
|
