Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments

Figure 1

Effects of HFD/STZ on glucose and insulin levels, and mechanical withdrawal thresholds. Time course of the effects of HFD/STZ ( rats) on (a) fasting plasma glucose and (b) fasting plasma insulin, in comparison with HFD/Veh treatment ( rats). At day 120 an oral glucose tolerance test (OGTT) was performed and plasma glucose (c) and plasma insulin (d) were quantified in the two groups of rats. (e) Mechanical withdrawal threshold of the hindpaws was measured twice weekly for up to 120 days. Data are mean ± SEM. Comparisons between HFD/STZ and HFD/Veh rats were performed with a Mann-Whitney test: , , and . For further analysis of the OGTT, comparisons to baseline values in each group were made using a Friedman test with Dunn’s post hoc test: HFD/Veh , , and ; HFD/STZ , , and .

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