Research Article
Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments
Figure 2
Effects of linagliptin and metformin on metabolic changes and mechanical withdrawal thresholds. Effects of linagliptin (3 mgkg−1, p.o.; ) or metformin (200 mgkg−1, p.o.; ) given daily from day 4 onwards on (a) fasting plasma glucose, (b) fasting plasma insulin, and (c) mechanical withdrawal thresholds in HFD/STZ rats, compared to the effects of vehicle in HFD/STZ rats (). Data from vehicle-treated HFD/Veh rats are also included for comparison as this group did not exhibit changes in mechanical withdrawal thresholds (). Linagliptin and metformin significantly prevented the decrease in hindpaw mechanical withdrawal thresholds in HFD/STZ rats compared to vehicle-treated HFD/STZ rats. Data are mean ± SEM. Analysis was by a Kruskal Wallis test with Dunn’s post hoc test: , , and (compared to HFD/Veh); , (compared to HFD/STZ).
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