Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments

Figure 3

Effects of the HFD/STZ model on mechanically evoked responses of dorsal horn neurons. Comparison of the mechanically evoked responses of wide dynamic range dorsal horn neurones following stimulation of the receptive field on the hindpaw with a range of innocuous and noxious von Frey hairs in the Lean/Veh controls, HFD/Veh controls, and diabetic HFD/STZ rats at (a) day 49 and (b) day 78. Data are mean frequency of firing ± SEM, rats per group, with an average of 15 neurones per group. (c) Representative trace of the evoked response of a single wide dynamic range dorsal horn neurone following mechanical (8, 10, 15, 26, and 60 g) stimulation of the hindpaw receptive field in the anaesthetised HFD/Veh rat.

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