Research Article
Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments
Figure 5
Effects of pioglitazone on metabolic changes and pain behaviour in HFD/STZ rats. Effects of pioglitazone treatment (10 mgkg−1, p.o.) versus vehicle from day 21–49, on (a) plasma glucose, (b) plasma insulin, and (c) hindpaw mechanical withdrawal thresholds in the HFD/STZ rat. Data are mean ± SEM. Group sizes day 0–49; Lean/Veh: ; HFD/Veh: ; HFD/STZ + vehicle: , HFD/STZ + pioglitazone: . Group sizes day 49 onwards; Lean/Veh: ; HFD/Veh: ; HFD/STZ + vehicle: ; HFD/STZ + pioglitazone: . Analysis was by a Kruskal-Wallis test with Dunn’s post hoc test: , , and (compared to HFD/Veh).
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