Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments

Table 1

Effects of the HFD/STZ model on electrically evoked responses of dorsal horn neurones.

	Lean/Veh	HFD/Veh	HFD/STZ
C-fibre threshold (mV)	1.5 ± 0.2	1.3 ± 0.1	1.2 ± 0.1
Latency (ms)	228 ± 13	189 ± 11	192 ± 19
Aβ (total APs)	138 ± 12	139 ± 8	111 ± 8
Aδ (total APs)	161 ± 24	123 ± 19	105 ± 21
C (total APs)	392 ± 67	251 ± 37	276 ± 48
Postdischarge (total APs)	440 ± 98	309 ± 48	402 ± 82

Comparison of thresholds for electrical activation of C-fibres, latencies of C-fibre evoked responses of WDR dorsal horn neurones, and electrically evoked responses of WDR neurones in the HFD/STZ model of diabetes, compared to HFD/Veh and Lean/Veh controls at day 49 after model induction ( neurones in rats per group). Data are mean ± SEM. There were no statistical differences between the groups (Kruskal Wallis test).