Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge

Figure 5

Temporal profile of insulin and zinc concentrations in the portal or splenic blood pool after injection of a dextrose bolus. Three pigs per sampling method are represented by the black dotted, dashed, and solid lines. The red curves shown are spline fits. Top row insulin (a) and zinc (b) release profiles from the transhepatic portal venous sampling technique. Bottom row insulin (c) and zinc (d) release profiles from the transhepatic splenic venous sampling technique. Note the biphasic insulin response with an associated clear rise of zinc concentration after the first peak at approximately 5 minutes.

(a)

(b)

(c)

(d)