Effect of Rosiglitazone and Insulin Combination Therapy on Inflammation Parameters and Adipocytokine Levels in Patients with Type 1 DM

Table 2

Comparison between the baseline and final (week 16) values for each group.

Parameters	Group 1; Insulin + rosiglitazone			Group 2; Insulin alone
	Baseline; (n = 30)	Final; (n = 28)		Baseline; (n = 31)	Final; (n = 28)
BW (kg)	66.59 ± 8.6	69.96 ± 9.29	0.003	63.13 ± 8.2	65.18 ± 8.20	0.001
BMI (kg/m^2)	24.17 ± 2.62	25.69 ± 2.57	0.002	22.97 ± 2.74	23.76 ± 2.73	<0.001
WC (cm)	83.80 ± 8.26	86.61 ± 8.53	0.107	78.71 ± 9.11	80.78 ± 8.09	0.109
WHR	0.85 ± 0.06	0.85 ± 0.05	0.792	0.80 ± 0.06	0.82 ± 0.06	0.048
SBP (mmHg)	114 ± 13.63	111.6 ± 13.7	0.604	116 ± 9.37	110.5 ± 9.62	0.030
DBP (mmHg)	75.25 ± 9.24	70.83 ± 9.11	0.061	75.95 ± 7.51	72.63 ± 7.70	0.174
FPG (mg/dL)	249.1 ± 69.5	219.7 ± 97	0.460	223.2 ± 78.5	178 ± 91	0.006
HbA1c (%)	9.22 ± 1.77	9.09 ± 1.40	0.239	8.75 ± 1.14	8.46 ± 1.19	0.050
eGDR (mg/kg/min)	8.53 ± 2.70	8.36 ± 2.45	0.185	9.25 ± 3.18	9.22 ± 3.20	0.235
Urea (mg/dL)	25.50 ± 7.17	26.66 ± 6.2	0.032	25.52 ± 6.03	27.84 ± 4.96	0.042
Cr (mg/dL)	0.83 ± 0.16	0.82 ± 0.26	0.935	0.86 ± 0.12	0.90 ± 0.31	0.602
ALT (IU/L)	18.25 ± 11.4	13.55 ± 4.3	0.033	15.85 ± 9.85	17.52 ± 13.3	0.912
Total-C (mg/dL)	172.8 ± 36.2	169.0 ± 31.8	0.935	177.3 ± 33.8	170.1 ± 34.5	0.678
HDL-C (mg/dL)	45 ± 5.90	47.80 ± 9.37	0.285	47.00 ± 9.35	51.47 ± 10.60	0.038
LDL-C (mg/dL)	105 ± 27.12	98.86 ± 27.89	0.688	111.15 ± 24.17	107.45 ± 30.1	0.668
TG (mg/dL)	113 ± 77.91	111.20 ± 52.41	0.971	79.47 ± 42.95	81.57 ± 27.14	0.821
FFA (mEq/L)	0.57 ± 0.43	0.53 ± 0.28	0.913	0.49 ± 0.25	0.47 ± 0.26	0.601
ACR (mg/min)	35.50 ± 42.91	23.57 ± 17.65	0.136	19.36 ± 19.00	12.54 ± 10.72	0.667
Hgb (g/dL)	13.72 ± 1.98	13.16 ± 1.98	0.015	13.74 ± 1.64	13.61 ± 1.04	0.838
HCT (%)	40.55 ± 5.48	39.06 ± 5.42	0.067	40.53 ± 4.44	40.65 ± 2.69	0.428
Resistin	6.96 ± 3.06	4.99 ± 2.64	0.006	7.16 ± 2.30	5.57 ± 2.48	0.031
Leptin	25.8 ± 17.6	20.1 ± 12.55	0.006	16.72 ± 16.1	14.0 ± 13.4	0.007
Adiponectin	17.48 ± 10.71	19.81 ± 11.21	0.145	11.90 ± 5.23	15.98 ± 9.47	0.948
Insulin dose (units/day)	64.45 ± 16.31	65.88 ± 15.29	NS	53.33 ± 13.45	52.78 ± 11.07	NS

BW: body weight; BMI: body mass index; WC: waist circumference; WHR: waist-to-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HbA1c: glycosylated hemoglobin; eGDR: estimated glucose disposal rate; CR: creatinine; AST: aspartate aminotransferase; ALT: alanine aminotransferase; Total-C: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; FFA: free fatty acids; ACR: albumin/creatinine ratio; Hgb: hemoglobin; Hct: hematocrit.