In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue

Figure 7

The ultrastructural changes of mice ASCs after 24 and 72 hours in the cultures treated with 1 mM, 5 mM, and 10 mM of metformin in comparison to the control culture. Typical ultrastructural features were indicated with proper abbreviations: nu: nucleus, en: endosomes, mv: microvesicles, and mt: mitochondria. Depicted images are representative, and were obtained from cultures carried out in duplicate.