Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice

Figure 9

Chronic treatment with E2HSA regulated the expression of Bcl-2 family proteins and FoxO1. Data are from pancreas tail samples. ((a)–(f)) The upper panels show 2 representative Western blots from each group. Protein bands were determined by densitometry analysis and expressed as fold change, after correction for -actin expression levels, relative to Con. mice. ((a), (f)) The ratio of phosphorylated protein to total protein of each group was first determined; then the fold change was calculated by comparing to Con. mice. Nor., db/m mice treated with normal saline. Con., db/db mice treated with normal saline. E2HSA (9), db/db mice treated with 9 mg/kg E2HSA. Data are expressed as mean ± S.E.M (-5). , , and versus Con.

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