KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus

Figure 1

ABCC8 and KNJ11 genes and their encoded proteins and functions. The KCNJ11 and ABCC8 genes are next to each other on chromosome 11p15.1. KCNJ11 is a single exon (dark box) gene encoding the Kir6.2 protein, and ABCC8 has 35 exons (dark boxes) encoding the SUR1 protein; both are subunits of the ATP-sensitive potassium (KATP) channel. Metabolism of glucose can affect ATP levels and thereby the function of the KATP channel. ABCC8: ATP-binding cassette transporter subfamily C member 8; KCNJ11: potassium inwardly-rectifying channel, subfamily J, member 11; Kir6.2: inward-rectifier potassium ion channel; SUR1: sulfonylurea receptor 1; NBD1: nucleotide-binding domain 1; NBD2: nucleotide-binding domain 2; N: NH2 terminal of protein; C: COOH terminal of protein; A: Walker A motif; B: Walker B motif; cAMP: cyclic adenosine monophosphate; ATP: adenosine triphosphate.