KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus

Figure 3

Cross-talk between the KCNJ11 gene and the other genes involved in the regulation of insulin secretion in pancreatic beta cells. KCNJ11 interacts with many genes, of which 10 are most prominent. KCNJ11 interacts with ABCC8 to produce the KATP channel, which transfers potassium ions across the beta cells. The KCNJ11 and ABCC8 genes interact with three groups of gene products at the cell membrane (white) and the intracellular (dark gray) levels. KATP: ATP-sensitive potassium channel; CACNA1A: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; CACNA1B: calcium channel, voltage-dependent, N type, alpha 1B subunit; CACNA1C: calcium channel, voltage-dependent, L type, alpha 1C subunit; CACNA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit; CACNA1E: calcium channel, voltage-dependent, R type, alpha 1E subunit; CACNA1G: calcium channel, voltage-dependent, T type, alpha 1G subunit; ABCC9: ATP-binding cassette transporter subfamily C member 9; KCNJ11: potassium inwardly rectifying channel, subfamily J, member 11; ABCC8: ATP-binding cassette transporter subfamily C member 8; ENSA: endosulfine alpha; PRKACG; protein kinase catalytic subunit G; RAPGEF4: rap guanine nucleotide exchange factor 4; FOXA2: forkhead box A2.