Charge-Based Inhibitors of Amylin Fibrillization and Toxicity

Figure 3

TEM images of aggregates formed by WT-amylin and charged variants. (a) WT amylin, (b) Arg-1, (c) Arg-2, and (d) Mem-T, after incubation for 2 days in 20 mM phosphate buffer, pH 7.4, at a temperature of 37°C. All peptide concentrations were 80 M.

(a)

(b)

(c)

(d)