Impaired Adipose Tissue Expandability and Lipogenic Capacities as Ones of the Main Causes of Metabolic Disorders

Figure 1

Lipogenic pathway in obese patients. The loss of the lipogenic capacity of the adipose tissue is compensated by other tissues and organs, mainly the liver. Thus, many molecules come into play in this loss of lipogenic capacity of the adipose tissue, acting in a wrong way. HFD: high fat diet; IR: insulin resistance; TAG: triacylglycerol; PPARγ: peroxisome proliferator-activated receptor-γ; FASN: fatty acid synthase; ZAG: zinc-α2 glycoprotein; FABP4: fatty acid-binding protein 4; RORγ1: retinoic acid receptor-related orphan nuclear receptor γ1; SCD1: stearoyl-CoA desaturase-1; Rab18: Ras-related protein 18; BrCa1: breast cancer 1.