Impaired Adipose Tissue Expandability and Lipogenic Capacities as Ones of the Main Causes of Metabolic Disorders

Figure 2

The adipose tissue expansion is produced via hypertrophy in a first point. If the surplus of energy continues, adipose tissue expansion will happen via hyperplasia and/or hypertrophy. In these mechanisms, different mechanisms intervene: adipogenesis, apoptosis, and/or angiogenesis, which will determine the metabolic status of the patient. Moreover, within each mechanism, this adipose tissue can be modulated. HFD: high fat diet; SFRP1: secreted frizzled-related protein 1; S14: thyroid hormone responsive Spot 14; VEGF-A/B/C/D: vascular endothelial growth factor A/B/C/D; TWEAK: TNF-like weak inducer of apoptosis; CASP3/7: Caspasas3/7; BCL2: B-cell lymphoma 2; TRAIL: TNF (tumor necrosis factor)-related apoptosis-inducing ligand.