Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Diabetic Rats Impairs Glycolytic Flux and Promotes Glycogen Synthesis

Figure 4

Type 2 diabetes mellitus (T2DM) modulates the expression of glycogen metabolism-related enzymes. (a) Pooled data of independent experiments, indicating the fold variation of glycogen synthase 1 (GYS1) and glycogen phosphorylase L (PYGL) mRNA levels found in testicles of T2DM rats when compared with the control rats (dashed line). (b) Pooled data of independent experiments, indicating the fold variation of GYS1 and PYG protein levels found in testicles of T2DM rats when compared with the control rats (dashed line). (c) Illustrative Western Blot experiment. Results are expressed as mean ± SEM ( for each condition). *Significantly different relative to control ().

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