Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes

Figure 3

Chronic treatment results in normalized hyperglycemia and improved glucose tolerance in db/db mice. (a) Glucose tolerance test in oleanolic acid-, metformin-, and combination-treated and untreated db/db mice. After three weeks of treatment with OA, metformin, and the combination, mice were fasted for 12 hours and then given glucose (1.5 g/kg). The blood glucose levels in the tail tip blood were measured at 0, 15, 30, 60, and 120 minutes after glucose administration. (b) One-way ANOVA of the area under curve showed that the drugs can significantly improve glucose tolerance in db/db mice compared with that in untreated db/db mice. Data are shown as the mean ± SEM. , , and indicate significant differences for comparisons with the vehicle group; indicates significant differences for comparisons with the monotherapy group ().

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