Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Figure 2

(a) OGTT in PSN632408- or vehicle-treated diabetic mice with normoglycaemia at 4 weeks after transplantation. PSN632408-treated mice () had significant decreases in glucose levels compared with vehicle-treated mice () after glucose challenge (, ). (b) Area under curve () during OGTT. was significantly decreased in PSN632408-treated mice () compared with vehicle-treated mice () (). (c) Blood glucose levels in PSN632408 () or vehicle-treated diabetic mice () with normoglycaemia before and after removal of left kidney bearing human islet grafts ().

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