Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Figure 3

(a) Immunofluorescent staining for insulin (red color) and DAPI (white color) in human islet grafts from the same donor under kidney capsules in PSN632408- and vehicle-treated mice at 4 weeks after transplantation. (b) Percentage of β-cell area in islet grafts. β-cell area in islet grafts of PSN632408-treated mice () was significantly increased compared with vehicle-treated mice () ().

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