Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

Figure 3

Possible influences of ligands on hIAPP aggregation. Schematic illustrating some of the possible mechanisms by which an inhibitor can affect aggregation: (a) monomer stabilization; (b) stabilization of off-pathway intermediates; (d and e) dissolution of fibers either completely to the monomeric state (d) or incompletely to another oligomeric form (e); (f) prevention of fiber extension. Note that this is not an exhaustive list of possible interactions.