Research Article

Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study

Table 1

Sample characteristics (22 discordant twin pairs).

Type 2 diabetes
Mean (SD) or (%)
No diabetes
Mean (SD) or (%)
value

Mean age (years)59.5 (5.3)59.5 (5.3)
Male sex 12 (55%)8 (36%)0.38
Years of education (years)12.9 (4.8)12.8 (5.3)0.88
Fasting glucose (mmol/L) 7.0 (1.5)5.7 (0.8)0.02
Hypertension14 (67%)6 (28%)0.04
Ischemic heart disease 2 (9%)0 (0%)0.50
Hypercholesterolemia12 (54%)11 (50%)0.98
Ever-smoking12 (57%)9 (41%)0.45
Systolic blood pressure (mmHg)151 (18.1)142 (17.9)0.05
Diastolic blood pressure (mmHg)83.8 (11.6)82.9 (8.5)0.86
Waist (cm) 107.2 (10.6)96.6 (16.2)0.004
Height (cm) 164.9 (21.4)166.4 (10.9)0.78
Weight (kg) 93.5 (14.9)84.1 (18.9)0.03
Mood score (GDS) 2.7 (2.6)2.2 (2.9)0.45
NART-R FSIQ107.9 (8.9)107.8 (8.5)0.93
HVLT delayed recall9.0 (2.5)9.8 (1.9)0.25
HVLT recognition11.5 (0.7)11.2 (1.1)0.25
Rey complex figure copy34.7 (1.8)34.7 (2.3)0.94
Rey complex figure delayed recall19.4 (6.1)19.5 (6.5)0.94
WMS3 mental control25.5 (6.1)25.3 (4.7)0.88
WMS3 digit span total18.5 (4.2)18.6 (3.9)0.83
PAL total errors (raw)27.9 (30.1)28.2 (31.5)0.96
SRT correct latency (mean)275.1 (62.4)258.2 (43.5)0.21
Total hippocampal volume (mL)4.5 (0.5)4.5 (0.6)0.99
Gray matter volume (mL)635.7 (63)644.2 (62)0.59
White matter volume (mL)461.4 (59)468.6 (52)0.55
White matter lesion volume (mL)4.6 (2.0)5.1 (3.3)0.31
MRI infarcts0 (0)0 (0)
Insulin therapy4 (18%)0 (0)<0.001
Oral antidiabetic agents20 (91%)0 (0)<0.001
Blood pressure agents18 (82%)7 (32%)<0.001
Cholesterol lowering agents17 (77%)5 (23%)<0.001
Duration of diabetes (years)10.1 (9.7)

for within-pair comparisons using paired -test (for continuous variables) and McNemar’s test (for categorical variables).
GDS: Geriatric Depression Scale; NART-R: National Adult Reading Test-Revised; HVLT: Hopkins verbal learning test; WMS3: Wechsler memory scale version 3; FSIQ: full scaled intelligence quotient; SRT: simple reaction time from the CANTAB; PAL: paired associates learning test from the CANTAB; SD: standard deviation; MRI: magnetic resonance imaging.