Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study
Table 3
Regions (and , , and coordinates) associated with reduced activation in type 2 diabetes.
All (22 pairs)
Region
Hemisphere
score
Middle temporal gyrus
L
20
4.64
401
Angular gyrus
L
34
3.36
Angular gyrus
L
36
3.35
Middle temporal gyrus
L
32
3.29
Inferior parietal lobule
L
26
3.22
Middle temporal gyrus
L
30
3.08
Middle temporal gyrus
L
4.39
399
Middle temporal gyrus
L
4.26
Middle temporal gyrus
L
3.43
Middle temporal gyrus
L
3.41
Middle temporal gyrus
L
4
3.32
Superior temporal gyrus
L
6
3.3
MZ (8 pairs)
Region
Hemisphere
score
Medial frontal gyrus
L
58
4
4.29
270
Medial frontal gyrus
L
48
18
4.27
Superior frontal gyrus
L
62
8
4.2
Medial frontal gyrus
L
48
14
4.16
Medial frontal gyrus
L
54
20
4.12
DZ (14 pairs)
Region
Hemisphere
score
Middle temporal gyrus
L
3.71
421
Middle temporal gyrus
L
3.5
Middle temporal gyrus
L
8
3.42
Middle temporal gyrus
L
3.32
Middle temporal gyrus
L
3.3
Middle temporal gyrus
L
3.09
Middle temporal gyrus
L
22
3.8
307
Angular gyrus
L
34
3.38
Middle temporal gyrus
L
30
3.34
Supramarginal gyrus
L
34
3.1
Middle temporal gyrus
L
30
3.04
Middle temporal gyrus
L
30
3.02
Covariates include gender (except in MZ comparisons), waist circumference, and history of hypertension. MZ: monozygotic; DZ: dizygotic. , , and refer to Montreal Neurological Institute voxel coordinates; regions are based on the Talairach Daemon; : peak voxel cluster; L: left hemisphere. All comparisons are within twin pairs and corrected for family-wise error (FWE) threshold of 0.05.
