Review Article
Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy
Table 2
Reported HATs/HDACs in DN.
| Enzyme category | Enzymes | Catalyzed site | Target renal loci | Effects in DN | References |
| HATs | CBP | H3K9/14, H4K5/8/12 | Human monocytes; RMCs | Inflammation; increased TGF-β1-induced genes expression | [30, 36] | GCN5 | | Akita mice renal cortex | Inflammation | [33] | P300 | H3K9/14 | Endothelial cell, diabetic rats; RMCs | Inflammation, FN, vasoactive factors; increased TGF-β1-induced genes expression | [36, 54, 56] | p/CAF | H3K9/14, H4K5/8/12; H3K18 | Human monocytes; Akita mice renal cortex; db/db mice, human renal proximal tubule epithelial cell line | Inflammation | [30, 57] |
| HDACs | HDAC1 | H3K9/14; H3K9, H3K18 | RMCs; Akita mice, HBZY-1 cell | Blocking TGF-β1-induced gene expression; affecting inflammatory factors | [33, 36] | HDAC2 | H3/H4 | Type1/2 murine models, NRK52-E cells | Promoting fibrosis | [68] | HDAC4 | | Db/db mice, STZ-induced rats, diabetic patients | Contributing to podocyte injury | [70] | HDAC5 | H3K9/14 | RMCs | Blocking TGF-β1-induced gene expression | [36] | SIRT1 | NF-κB, STAT3 | Renal tubular cells, podocyte; GMCs; db/db mice; diabetic fa/fa rats | Attenuating albuminuria; inhibiting cell apoptosis; attenuating kidney injury; regulating autophagy; reducing oxidative stress | [47, 75–80, 82–84] |
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