Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway

Figure 6

Curcumin inhibited high glucose-induced apoptosis and oxidative stress via activation of Akt in cardiomyocytes. (a) Curcumin upregulated Akt and GSK-3β phosphorylation levels. (b) Increased Akt and GSK-3β phosphorylation by curcumin were abolished by treatment with LY294002. (c) The effects on the Bcl-2/Bax ratio and the expression of and by curcumin were blocked by treatment with LY294002. . Values are presented as mean ± SD. versus NG group. versus HG group. versus curcumin treatment group.

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