Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
Table 1
Metabolic parameters of rats.
Groups
Body weight (g)
FBG (mmol/L)
Fins (mU/L)
TG (mmol/L)
TC (mmol/L)
Adiponectin (g/L)
HOMA-IR
HMW-adiponectin (g/L)
Control ()
318.1 ± 6.9&
4.96 ± 0.25&
21.85 ± 2.30
0.34 ± 0.04&
1.32 ± 0.04&
0.52 ± 0.06&
4.81 ± 0.48&
0.43 ± 0.11&
D ()
457.8 ± 25.0
7.43 ± 0.83
21.37 ± 1.60
0.78 ± 0.06
2.16 ± 0.07
0.47 ± 0.04
7.35 ± 0.74
0.34 ± 0.09
DI ()
450.6 ± 6.0
5.23 ± 0.34
25.66 ± 1.88
0.75 ± 0.07
2.15 ± 0.07
0.47 ± 0.03
5.81 ± 0.37&
0.38 ± 0.08
DE ()
318.7 ± 10.7&
5.10 ± 0.33
23.20 ± 1.47
0.52 ± 0.04&
1.30 ± 0.08&
0.76 ± 0.03
5.27 ± 0.59&
0.70 ± 0.07
FBG, fasting blood glucose; FFA, free fatty acids; FIns, fasting plasma insulin; kg twice daily; Control, rats fed normal chow diet; TC, total cholesterol; TG, triglyceride. Data are means ± s.e. Compared with the Control group: < 0.05; compared with the D group: & < 0.05.