Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes
Table 3
The effects of the combination of sex and metabolic status-abnormalities on the annual eGFR decline.
Sex
Clinical feature
Annual eGFR change (%/year)
P value
Male
HbA1c < 7.0% (53.0 mmol/mol)
43
−1.4 ± 1.9
0
—
HbA1c ≥ 7.0% (53.0 mmol/mol)
204
−2.2 ± 2.2
−0.055
0.464
Female
HbA1c < 7.0% (53.0 mmol/mol)
13
−2.7 ± 1.4
−0.083
0.139
HbA1c ≥ 7.0% (53.0 mmol/mol)
84
−3.6 ± 2.9
−0.234
0.003
Male
LDL-cholesterol < 3.4 mmol/L
146
−2.1 ± 2.3
0
—
LDL-cholesterol ≥ 3.4 mmol/L
101
−2.0 ± 2.0
0.030
0.577
Female
LDL-cholesterol < 3.4 mmol/L
38
−3.1 ± 1.8
−0.090
0.108
LDL-cholesterol ≥ 3.4 mmol/L
59
−3.8 ± 3.2
−0.189
0.001
Male
SBP < 140 mmHg
147
−1.8 ± 2.0
0
—
SBP ≥ 140 mmHg
100
−2.4 ± 2.4
−0.019
0.561
Female
SBP < 140 mmHg
40
−2.8 ± 2.6
−0.117
0.033
SBP ≥ 140 mmHg
57
−4.0 ± 2.7
−0.207
<0.001
Data are presented as means ± SD. Adjusted for baseline age, diabetes duration, DR, proteinuria, overweight, ever-smoker, HbA1c (except for first model), LDL-cholesterol (except for second model), and SBP (except for third model).
