Journal of Diabetes Research / 2016 / Article / Tab 1 / Review Article
Variations in the Obesity Gene “LEPR ” Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis Table 1 General characteristics of the studies included in this meta-analysis.
SNP First author Ethnicity Case Control Age (mean ± SD) Genotype frequency BMI (kg/m2 ) MAF Case Control Case Control Case Control R223Q Jiang [13 ] Chinese 369 176 68.0 ± 6.4 67.1 ± 7.1 4/65/273 3/33/117 25.0 ± 4.0 23.1 ± 3.3 0.42
Mohammadzadeh [16 ] Iranian 144 147 54.3 ± 8.9 52.5 ± 7.3 5/59/80 5/62/80 27.6 ± 4.5 28.0 ± 4.0 Gan [11 ] Chinese 301 172 52.7 ± 10.7 52.8 ± 8.0 18/83/200 4/47/121 24.8 ± 2.3 24.8 ± 1.7
Murugesan [19 ] Indian 150 150 NA NA 53/67/30 22/55/73 26.2 ± 3.6 24.1 ± 3.4
Etemad [10 ] Malaysian 145 133 NA NA 42/17/86 22/20/91 NA NA
Etemad [10 ] Chinese 49 71 NA NA 13/0/36 6/5/60 NA NA
Etemad [10 ] Indian 90 77 NA NA 37/7/46 23/15/39 NA NA Han [12 ] Korean 407 345 59.7 ± 9.62 64.5 ± 3.4 4/92/311 8/69/266 24.8 ± 3.1 24.0 ± 3.2
Takahashi-Yasuno [20 ] Japanese 220 377 NA NA 66/154† 97/279† NA NA Liao [14 ] Taiwanese 999 45 NA NA 8/194/796 1/8/36 NA NA Kyong [17 ] Korean 775 688 58.9 ± 10.5 64.2 ± 4.2 11/177/578 13/148/523 24.4 ± 2.9 23.6 ± 3.1 R109K Jiang [13 ] Chinese 369 176 68.0 ± 6.4 67.1 ± 7.1 3/81/184 3/35/72 25.0 ± 4.0 23.1 ± 3.3 0.32 Murugesan [19 ] Indian 150 150 NA NA 10/40/100 10/48/91 25.7 ± 4.8 24.7 ± 3.6 Cruz [21 ] Mexican 519 547 53.4 ± 7.4 43.6 ± 6.6 NA NA 29.3 ± 4.8 27.5 ± 3.6 Kyong [17 ] Korean 775 688 58.9 ± 10.5 64.2 ± 4.2 31/238/496 22/200/461 24.4 ± 2.9 23.6 ± 3.1 Qu [18 ] Chinese 317 282 49.3 ± 13.7 45.2 ± 5.7 11/93/213 8/71/203 25.5 ± 4.1 23.8 ± 2.9 Liao [14 ] Taiwanese 999 80 NA NA 23/265/705 1/29/50 NA NA Han [12 ] Korean 407 345 59.7 ± 9.62 64.5 ± 3.4 16/122/269 11/97/235 24.8 ± 3.1 24.0 ± 3.2 K656N Jiang [13 ] Chinese 369 176 68.0 ± 6.4 67.1 ± 7.1 0/34/226 0/9/96 25.0 ± 4.0 23.1 ± 3.3 0.14 Murugesan [19 ] Indian 150 150 NA NA 9/52/89 13/51/86 25.8 ± 4.3 24.7 ± 4.0 Kyong [17 ] Korean 775 688 58.9 ± 10.5 64.2 ± 4.2 4/111/650 3/84/596 24.4 ± 2.9 23.6 ± 3.1 Qu [18 ] Chinese 317 282 49.3 ± 13.7 45.2 ± 5.7 1/27/289 1/32/249 25.5 ± 4.1 23.8 ± 2.9 Han [12 ] Korean 407 345 59.7 ± 9.62 64.5 ± 3.4 0/57/350 0/38/305 24.8 ± 3.1 24.0 ± 3.2 P1019P Lu [15 ] Chinese 216 108 NA NA 132/33/51 49/17/42 27.0 ± 4.1 22.3 ± 2.2 0.31 Takahashi-Yasuno [20 ] Japanese 220 377 NA NA 57/163† 102/274† NA NA Qu [18 ] Chinese 317 282 49.3 ± 13.7 45.2 ± 5.7 4/69/244 4/53/225 25.5 ± 4.1 23.8 ± 2.9 3′UTR Lakka [22 ] Finland 41 81 52.9 ± 6.0 52.9 ± 6.4 1/3/37 0/19/62 NA NA NA
Nannipieri [23 ] Mexican 503 609 NA NA 7/124/372 29/167/413 NA NA S343S Kyong [17 ] Korean 775 688 58.9 ± 10.5 64.2 ± 4.2 4/103/659 3/63/616 24.4 ± 2.9 23.6 ± 3.1 0.25 N567N Kyong [17 ] Korean 775 688 58.9 ± 10.5 64.2 ± 4.2 0/3/769 0/7/676 24.4 ± 2.9 23.6 ± 3.1 NA
BMI: body mass index; NA: not available; MAF: minor allele frequency.† Only genotype counts in dominant model can be extracted from the original study.
