CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance
Table 3
Distribution of CCL2 (G-2518A) and CCR2 (Val64Ile) gene polymorphism in Mexican-Mestizo population.
Genotype, (%)
Phenotype, (%)
Allele, (%)
Study group
CCL2 G-2518A
G/G
G/A
A/A
A+
A−
G
A
Individuals without IR
47 (17.4)
135 (50.0)
88 (32.6)
223 (82.6)
47 (17.4)
229 (42.4)
311 (57.6)
Individuals with IR
32 (29.0)
51 (46.4)
27 (24.6)
78 (70.9)
32 (29.1)
115 (52.3)
105 (47.7)
0.01378
0.01131
0.01321
Genotype, (%)
Phenotype, (%)
Allele, (%)
Study group
CCR2 Val64Ile
Val/Val
Val/Ile
Ile/Ile
Ile+
Ile−
Val
Ile
Individuals without IR
173 (64.1)
82 (30.4)
15 (5.5)
97 (35.9)
173 (64.1)
428 (79.3)
112 (20.7)
Individuals with IR
67 (60.9)
37 (33.6)
6 (5.5)
43 (39.1)
67 (60.9)
171 (77.7)
49 (22.3)
0.64924
0.94889
0.63925
. IR: insulin resistance. Significant differences: Pearson’s goodness-of-fit test or Fishers’ exact test; G or Val: wild-type alleles; A+ phenotype: A/A plus G/A genotypes; Ile+ phenotype: Ile/Ile plus Ile/Val genotypes.
