A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies

Figure 1

(a) Blood glucose and (b) HbA1c levels in the serum of normal (NDC) and diabetic (D) rats 4 weeks after STZ injection. The D rats were treated either by topical administration with vehicle (white petrolatum jelly) alone, or with a 1% or 3% suspension of CMC2.24 (D + 1% 2.24 or D + 3% 2.24, resp.), or by oral intubation with 30 mg/kg CMC2.24 suspended in 2% carboxymethylcellulose (D + 30 mg 2.24). The topical and systemic CMC2.24 treatments were administered daily during the final 7 days of the protocol, 3 weeks after inducing diabetes. Each value is the mean ± standard error of mean (SEM) of 3 rats per group. (c) The typical clinical appearance of the skin wounds from each of the five experimental groups 7 days after initiating the daily topical and systemic treatments. A value ≤ 0.05 was considered statistically significant.

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