The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Figure 2

Development of diabetes in NOD mice. (a) Proportion of mice (percentile) having normal glucose levels defined as nonfasting BG below 10 mmol/L from day 0 to day 56. (b) Number of normoglycemic versus diabetic animals at day 56. Statistical significance was obtained between the variables (, Fisher’s exact test) with a higher incidence of diabetes in the vehicle group ((a) and (b)). (c) Morning fed BG during a time period from day −7 to day 56. (d) Plasma insulin levels at day 56. Unpaired -test . ((c) and (d)) Data are presented as mean ± SEM (–20/group). (c) Two-way ANOVA w/Bonferroni post hoc test. (d) Unpaired -test. ((c) and (d)) compared to vehicle.

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(b)

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