The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Figure 5

Immune cell distribution and expression of proinflammatory cytokines in NOD mice pancreata. Immunohistochemistry staining of the immune cells in pancreatic islets of vehicle (left) and SER140 treated (right) mice at day 56 of treatment, for (a) CD3, (b) CD20, and (c) F4/80. Arrows indicate F4/80⁺ cells. In situ hybridization analysis of the expression of genes encoding the proinflammatory cytokines IL-6 (d), TNF-α (e), and IFN-γ (f) in and around pancreatic islets (red dots, arrows) in vehicle versus SER140 treated mice at day 56 of treatment ((d)–(f)). ((a)–(f)) Left: vehicle, right: SER140 treated. Scale bars = 100 μm.

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