Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy

Figure 3

Enrichment analysis of JASPAR transcription factor binding sites (TFBSs). Putative TFBSs were evaluated in both the WNT pathway gene set and across the entire genome for enrichment using the hypergeometric distribution with Bonferroni correction for multiple testing (the red line indicates ). TFAP2A, MZF1, and SP1 were significantly enriched across WNT pathway genes (, 1.34 × 10⁻¹¹, and 3.01 × 10⁻⁶, resp.). TFBS sequence motifs are illustrated with the height of each base indicative of the probability of the presence of the corresponding base at the designated position.