Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study
Table 5
Serum biochemistry parameters in rats orally treated with YL and OL extracts of V. amygdalina.
Parameters
Normal control
Negative control
Positive control
10 mg/kg YL
30 mg/kg YL
300 mg/kg YL
10 mg/kg OL
30 mg/kg OL
300 mg/kg OL
Liver function test
AST (U/L)
156.48 ± 6.06
321 ± 3.04
165.02 ± 2.23
243.39 ± 4.17
201.92 ± 5.10
166.04 ± 7.18
248.03 ± 2.01
208.05 ± 3.30
189.20 ± 6.10
ALT (U/L)
49.00 ± 2.56
192 ± 5.01
69.20 ± 1.25
112.08 ± 3.30
98.50 ± 1.86
75.13 ± 3.07
101.32 ± 4.53
87.25 ± 0.17
69.17 ± 12.6
ALP (U/L)
503.88 ± 2.79
603 ± 3.43
538.20 ± 0.32
573.25 ± 1.07
561.75 ± 4.38
528.25 ± 6.59
580.03 ± 1.32
566.11 ± 0.59
532.21 ± 2.11
TP (g/dL)
88.16 ± 0.20
77.02 ± 41.01
83.06 ± 2.56
80.30 ± 3.12
81.07 ± 3.30
86.03 ± 1.84
80.22 ± 0.25
80.29 ± 1.04
84.23 ± 6.52
TB (Umol/L)
15.01 ± 0.44
16.25 ± 0.73
15.41 ± 0.22
16.12 ± 0.45
16.01 ± 1.45
15.82 ± 0.06
16.15 ± 1.12
16.08 ± 0.13
15.90 ± 1.54
Lipid profile
TC (mmol/L)
4.02 ± 0.26
8.04 ± 3.04
4.54 ± 3.02
6.28 ± 0.39
5.31 ± 0.20
4.26 ± 0.32
7.01 ± 0.23
5.81 ± 1.62
4.91 ± 2.01
Triglyceride (mmol/L)
1.48 ± 0.07
2.51 ± 0.04
1.82 ± 0.06
2.23 ± 0.13
1.85 ± 0.14
1.70 ± 0.09
2.40 ± 1.05
1.87 ± 0.05
1.08 ± 0.11
HDL-C (mg/dL)
51.30 ± 0.01
18.07 ± 0.45
48.43 ± 3.13
24.14 ± 0.16
37.42 ± 0.03
50.51 ± 0.05
22.21 ± 0.40
33.32 ± 0.25
50.03 ± 0.38
LDL-C (g/dL)
66.07 ± 0.27
177.32 ± 2.45
67.17 ± 0.34
81.48 ± 0.33
75.30 ± 0.16
69.08 ± 0.24
84.60 ± 3.30
80.21 ± 0.31
73.35 ± 0.27
VLDL-C (mg/L)
11.79 ± 0.01
39.03 ± 1.08
11.85 ± 3.32
18.90 ± 0.01
12.78 ± 0.02
11.91 ± 0.02
22.25 ± 1.18
17.01 ± 0.28
12.63 ± 0.27
Values are expressed as mean ± SEM (); was considered statistically significant. = statistical difference between treated groups and negative control. Aspartate aminotransferase, AST; alanine aminotransferase, ALT; alkaline phosphatase, ALP; total protein, TP; total bilirubin, TB; total cholesterol, TC; triacylglycerol, TAG; low density lipoprotein cholesterol, LDL-C; high density lipoprotein cholesterol, HDL-C; very low density lipoprotein cholesterol, VLDL-C.
