Metformin Treatment Prevents Sedentariness Related Damages in Mice

Figure 1

METF prevention of sedentariness induced damage in adult male mice C57BL/6. (a) Experimental protocol. (b) Weight and glycemia variation. (c) Muscular performance evaluation reveals that METF treatment ameliorated the muscular performance. (d) Muscle tissue analysis indicated that METF had a positive action on AKT activation. (e) Western blot liver analysis showed that METF increased AMPK activation and decreased ERKs activation. (f) Liver morphological studies: METF increased CAMKII signal. Representative immunoblots of analyzed proteins are shown. Scale bar 200 μm. Significance: .

(a)

(b)

(c)

(d)

(e)

(f)