Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease

Table 5

Regions where functional activation correlated with response time.

Regions	Cluster size	Peak -Score (df = 81)	Montreal Neurological Institute coordinate for Peak -Score
Regions with activation positively correlated with response time
Right inferior frontal gyrus	958	4.40	2, −12, 4^1
Left precentral gyrus	654	4.57	−62, −10, 28^2
Left superior occipital gyrus	366	6.05	−18, −92, 34^3
Regions with activation negatively correlated with response time
Left superior parietal lobule	130	−3.95	−20, −50, 73^4

This table reports the spatial distribution of the association of length of response time with the mean brain activation (obtained from the DSST > control condition contrast), including the size of cluster, the maximum statistic for the cluster, and the location of the maximum statistic in Montreal Neurological Institute coordinates. The corrected alpha is the probability of false positive detection based on the combination of individual voxel probability thresholding and minimum cluster size thresholding.
¹This cluster includes the lower portion of the right pre- and postcentral gyri and it extended medially to include the thalamus.
²This cluster extended caudally to include the left postcentral gyrus.
³This cluster extends rostrally to include the left and right cuneus.
⁴This cluster includes the left precuneus.