Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects
Table 4
Multivariate logistic regression for effect of insulin resistance on lipoprotein subfraction profile.
Variables (%)
Raw data
Model A
Model B
OR
95% CI
AOR
95% CI
AOR
95% CI
VLDL
Non-IR group
1.000
1.000
1.000
IR group
1.974
[0.921; 4.230]
2.205
[0.965; 5.038]
2.332
[1.007; 5.404]
HDL2
Non-IR group
1.000
1.000
1.000
IR group
0.283
[0.141; 0.571]
0.267
[0.129; 0.552]
0.230
[0.108; 0.493]
HDL3
Non-IR group
1.000
1.000
1.000
IR group
0.322
[0.160; 0.645]
0.302
[0.146; 0.625]
0.298
[0.142; 0.625]
HDL5
Non-IR group
1.000
1.000
1.000
IR group
1.850
[0.881; 3.884]
1.843
[0.873; 3.890]
1.897
[0.890; 4.044]
HDL6
Non-IR group
1.000
1.000
1.000
IR group
3.367
[1.460; 7.766]
3.726
[1.579; 8.793]
3.936
[1.631; 9.498]
HDL7
Non-IR group
1.000
1.000
1.000
IR group
1.926
[0.919; 4.038]
1.927
[0.917; 4.047]
1.980
[0.930; 4.216]
HDL8
Non-IR group
1.000
1.000
1.000
IR group
2.305
[1.504; 5.039]
2.305
[1.042; 5.098]
2.363
[1.025; 5.445]
HDL9
Non-IR group
1.000
1.000
1.000
IR group
1.631
[0.772; 3.446]
1.367
[0.771; 3.474]
1.755
[0.806; 3.822]
HDLLARGE
Non-IR group
1.000
1.000
1.000
IR group
0.249
[0.123; 0.505]
0.232
[0.111; 0.484]
0.213
[0.099; 0.457]
HDLINTERMETDIATE
Non-IR group
1.000
1.000
1.000
IR group
3.367
[1.460; 7.766]
3.843
[1.606; 9.197]
4.698
[1.855; 11.901]
HDLSMALL
Non-IR group
1.000
1.000
1.000
IR group
2.400
[1.099; 5.239]
2.429
[1.110; 5.319]
2.486
[1.115; 5.543]
LDLSMALL
Non-IR group
1.000
1.000
1.000
IR group
2.826
[1.263; 6.324]
2. 794
[1.237; 6.310]
3.075
[1.341; 7.051]
Phenotype non-A
Non-IR group
1.000
1.000
1.000
IR group
3.011
[1.424; 6.366]
3.001
[1.404; 6.416]
3.176
[1.469; 6.867]
. Model A: adjusted for gender and age. Model B: adjusted for gender, age, smoking, statin, and fibrate. VLDL: very low-density lipoprotein; HDL-C: high-density lipoprotein cholesterol; non-IR group: individuals without insulin resistance; IR group: with insulin resistance.
