The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Figure 2

Hypothetical drawing of the effect of hyperglycemia on the increase of oxidative metabolism that induces damage to the mtDNA, which leads to mitochondrial dysfunction. The increase in the production of ROS augments damage to the nDNA with the generation of the product 8-OHdG and the decrease in repair of the DNA in DPN, which can ultimately cause axonal degeneration and cell death.