Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial

Figure 3

Wound healing histopathological analysis. Representative microscope photographs of ulcers in each treatment group are shown. (a) Hematoxylin-eosin staining, asterisks and arrows indicate inflammatory cells. (b) Masson’s trichrome staining shows that PDF + M-DDO induced an abundant synthesis of ECM, and its accumulation in healed ulcers is evident when compared to KTS. In addition, the ordered deposition of collagens is clear. Photos were taken with 40x and 20x objective.

(a)

(b)